Feline Distemper (or Feline Panleukopenia Virus)

What is Feline Distemper / FPV in Cats?

FPV / Feline Panleukopenia Virus, otherwise known as Feline Distemper, is a highly contagious, life-threatening infectious disease in cats. It mostly affects kittens and unvaccinated cats, and it can be fatal if not appropriately diagnosed and treated. It is closely related to canine parvovirus (often confused as it is not related to the canine distemper virus).

The feline panleukopenia virus infects and kills the rapidly growing and dividing cells in the body, including cells in the bone marrow, intestines, and skin, and in a developing fetus.

The virus suppresses the production of all white blood cells in the bone marrow. These cells are important to the immune system and are used to fight infection. Without them, the cat is vulnerable to spreading the virus.

Infected cells in the intestines eventually lead to diarrhea, decreased appetite and vomiting. Severe dehydration ensues and the safety barrier between the intestines and the rest of the body breaks down, leading to secondary bacterial infections. The virus spreads quickly and is fatal, if left untreated.

Feline distemper virus is found everywhere in the environment; it is strong and can live for years. The virus can survive in the environment it was shed into or be carried on shoes, paws, bedding, bowls, litter boxes, etc. It can survive at freezing temperatures and room temperatures, and it can also survive the use of certain disinfectants, including iodine and alcohol.

The virus enters the body through the nose or mouth; the specific cat’s immune system determines the number of viral particles that enter the body. Usually, the virus invades the bone marrow and intestines within two to seven days of the cat coming into contact with the virus.

Panleukopenia is considered one of the deadliest cat diseases in the unvaccinated cat population. Kittens, cats with depressed immune systems and pregnant cats are at the highest risk to develop severe clinical signs of this disease.

Symptoms of Feline Distemper / FPV

Symptoms of feline distemper can range from mild to severe and may include the following:

• Lethargy

• Depression

• Vomiting

• Diarrhea

• Painful abdomen (when touched or may appear tense and distended without touching)

• Dehydration

• Weight loss

• Rough or unkempt hair coat

• Fever

• Decreased to absent appetite

• Collapse (in severe cases)

• Bruising of the skin or gums (in severe cases)

Kittens infected in the womb during the late stages of pregnancy may develop cerebellar hypoplasia once born, a condition where the virus affects the formation of a part of the brain called the cerebellum. This is the part that coordinates balance and movement.

Affected kittens will have mild to severe intention tremors and a wide-based stance. They may fall frequently or seem uncoordinated. Luckily, this is not considered a painful condition, and these special-need kittens, if kept in safe environments, can live long happy lives.

Causes of Feline Distemper / FPV

Cats become infected with this virus in utero due to their mother becoming infected while pregnant or being exposed to it in their environment. Kittens can also be infected in utero or via breast milk when feeding from their mother.

A cat carrying feline distemper virus will shed viral particles into the environment through feces, urine, saliva and vomit. Infection occurs when susceptible cats are in contact with these secretions.

Luckily, an infected cat only sheds the virus for a day or two, but since the virus is very stable in the environment, it can live for years. That is why it is common for cats to become infected due to their environment.

Diagnosing Feline Distemper / FPV

Feline panleukopenia can look like many other conditions, such as feline leukemia or feline immunodeficiency virus. Any kitten showing signs of fever, vomiting, diarrhea, depression, and a decreased appetite is a feline panleukopenia suspect. A thorough medical history can be helpful with diagnosis, especially if your cat was recently adopted, has been outdoors frequently, is unvaccinated, and/or has been around other cats.

Your veterinarian will likely do bloodwork to help with the diagnosis. Feline panleukopenia is suspected when exposure history is correlated with very low white blood cells and possibly low red blood cells (anemia).

Fecal testing for feline panleukopenia virus can be performed . If the cat received a panleukopenia vaccine 5-12 days prior to testing, this form of test is often falsely positive. Virus isolation (a test to find the virus in different tissue samples), antibody levels and PCR testing are also available to help confirm suspicions of feline panleukopenia.

Treatment of Feline Distemper / FPV

There is no specific treatment for feline panleukopenia. Dehydration is treated with aggressive intravenous fluid therapy while clinical signs of vomiting and diarrhea are treated with prescription medications.

Antibiotic therapy is often instituted to help control any secondary bacterial infections due to low white blood cell counts. However, antibiotics are not used to treat and clear the actual virus. For kittens and cats who appear in shock, or with severe infections, aggressive therapy and nursing care is necessary for resuscitation, using plasma/blood transfusions and anti-coagulant therapies.

Luckily, cats who do receive and respond well to aggressive therapy during the first few days of feline panleukopenia tend to have a good prognosis for a complete recovery. Kittens infected in utero during the early to middle stages of pregnancy typically do not survive. Those infected in the later stages of pregnancy tend to develop cerebellar hypoplasia but can live happy lives with normal survival times, depending on the severity of the neurological signs.

Prognosis decreases for cats with low protein levels, low temperatures, thin body conditions, and/or severely low white blood cells on bloodwork. These extremely ill cats have a poor prognosis and, on average, will pass away within 12-24 hours.

If a cat recovers from feline panleukopenia, there is usually no permanent damage to their organs, and they develop lifelong immunity to the virus.

---

Hear From Us Again

Don't forget to subscribe to our email newsletter for more recipes, articles, and clinic updates delivered straight to your e-mail inbox.

Related Categories:

Cat Health

Chronic Kidney Disease in Cats

What is chronic kidney disease in cats?

Chronic kidney disease (CKD) is the persistent loss of kidney function over time. Healthy kidneys perform many important functions, most notably filtering the blood and making urine, so problems with kidney function can result in a variety of health problems for a cat. Among the many different kidney diseases that may affect cats, CKD is the most common.

The kidneys are part of the renal system, the body’s system for filtering impurities out of the blood. Urine produced in the kidneys is carried to the bladder by the ureters and from the urinary bladder to the outside world by the urethra.

Clinical Signs and Symptoms of Chronic Kidney Disease in Cats

Cats with CKD may experience a buildup of the waste products and other compounds in the bloodstream that are normally removed or regulated by the kidneys. This accumulation may make them feel ill and appear lethargic, unkempt, and lose weight. They may also lose the ability to concentrate their urine appropriately, and as a result they may urinate greater volumes and drink more water to compensate. The loss of important proteins and vitamins in their urine may contribute to abnormal metabolism and loss of appetite. They may also experience elevated blood pressure (hypertension), which can affect the function of a number of important systems, including the eyes, brain, and heart.

Another cause of lethargy in cats with CKD is the buildup of acids in their blood. The kidneys of cats with CKD may not excrete these compounds appropriately, making affected cats prone to blood acidification, or acidosis, a condition that can significantly affect the function of a variety of organ systems in the body. CKD may also decrease a cat’s ability to produce red blood cells, which can lead to anemia, a reduced concentration of red blood cells in their blood. This may cause their gums to appear pale pink, or in severe cases, whitish in color, and may make them lethargic.

Diagnosis of Chronic Kidney Disease in Cats

To evaluate kidney function, veterinarians will most often turn to blood tests and urine analysis (urinalysis) to evaluate the concentrations of waste products and other components that healthy kidneys normally filter or regulate.

Blood tests can determine the concentration of two important waste products: blood urea nitrogen (BUN) and creatinine, but creatinine is generally recognized as a more specific indicator of kidney function. An increase in the concentration of these compounds in your cat’s blood may suggest that his kidneys are not functioning properly, although these values must be interpreted in light of a number of factors. Dehydration, for example, can cause BUN and creatinine concentrations to increase in spite of the fact that a cat’s kidneys are functioning normally. Ideally, a veterinarian will base his or her interpretation of kidney function on at least two blood samples, obtained within two weeks of one another, from a normally hydrated cat that has fasted for 12-24 hours. The concentrations of other blood components, including various electrolytes (like sodium and potassium), phosphorus, red blood cells, and proteins are also important to evaluate in a cat being examined for CKD.

In a urinalysis, your veterinarian will consider the concentration of the urine, its pH, and the presence of protein, blood cells, bacteria, and other cells that generally should not be found in feline urine, all of which provide important information regarding the health of a cat’s kidneys. It is also important to culture a urine sample to rule out the possibility of bacterial infection of the urinary tract in suspected cases of CKD. Urine samples may be obtained either by collection from a litter box filled with non-absorbent beads designed for this purpose, by catheterization of the urethra (the opening of the urinary tract to the outside world), or by cystocentesis, a technique that extracts a urine sample by passing a very fine needle through the abdominal wall into the bladder. Cystocentesis is generally considered a safe procedure and in most cases will provide the most diagnostically useful sample for analysis.

Other studies that can be useful in evaluating a cat with suspected CKD include imaging studies such as abdominal ultrasound, radiographs (X-rays), and, in some cases, microscopic evaluation of biopsy samples. Given the potential for hypertension in cats with CKD, measurement of a cat’s blood pressure is also an important part of the medical evaluation for this disease.

Treatment of Chronic Kidney Disease in Cats

Although there is no definitive cure for CKD, treatment can improve and prolong the lives of cats with this disease. Therapy is geared toward minimizing the buildup of toxic waste products in the bloodstream, maintaining adequate hydration, addressing disturbances in electrolyte concentration, supporting appropriate nutrition, controlling blood pressure, and slowing the progression of kidney disease.

Dietary modification is an important and proven aspect of CKD treatment. Studies suggest that therapeutic diets that are restricted in protein, phosphorus and sodium content and high in water-soluble vitamins, fiber, and antioxidant concentrations may prolong life and improve quality of life in cats with CKD. However, many cats have difficulty accepting therapeutic diets, so owners must be patient and dedicated to sticking to the plan. It is important to make a gradual transition to a therapeutic diet and to consider food temperature, texture, and flavor. Cats with CKD that go without food for relatively short periods of time may develop significant health problems, so it is crucial to make sure that your cat is eating during a transition to a therapeutic diet.

Controlling hypertension, decreasing urinary protein loss, and addressing anemia are important therapeutic goals in cats that develop these conditions. Hypertension is usually controlled with oral medication, and urinary protein loss may be treated with angiotensin converting enzyme inhibitors. Anemia in a cat with CKD may be treated by replacement therapy with erythropoietin (or with related compounds), which stimulates red blood cell production. Cats with CKD may produce less erythropoietin, and there is some evidence that replacement therapy can increase red blood cell counts. In some cases, blood transfusions, which may be used to restore normal red blood cell concentrations using blood obtained from a donor cat, may be necessary.

Although a number of other therapies, including phosphate binders, potassium supplementation, antioxidant supplementation, alkalinization therapy, and administration of fluids either intravenously or subcutaneously, have the potential to help cats with CKD, these approaches have not been fully validated, and controlled studies are needed to determine whether they offer any benefits. The same is true of hemodialysis (the removal of toxic waste products from the bloodstream by specially designed equipment) and kidney transplantation. These controversial, complex, and expensive treatments offer potential benefits to cats with CKD, but they have not been subjected to studies to prove their effectiveness, so they should be explored with the careful guidance of a veterinary specialist.

Prognosis of Chronic Kidney Disease in Cats

Some cats respond very well to treatment for CKD while others do not, so the prognosis for CKD in affected cats is quite variable. Some studies suggest that cats that lose more protein in their urine have less favorable prognoses. There is evidence suggesting that the earlier CKD is diagnosed and treatment is initiated, the better the outcome with respect to quality of life and survival.

---

Hear From Us Again

Don't forget to subscribe to our email newsletter for more recipes, articles, and clinic updates delivered straight to your e-mail inbox.

Related Categories:

Cat Health

Cat Vomiting, Diarrhea, Bloody Stool - Irritable Bowel Disease in Cats

Overview and Risk

Inflammatory bowel disease (IBD) is a condition that results when your cat’s immune system turns against the lining of their gastrointestinal (GI) tract, resulting in impaired absorption of nutrients and the ability to digest food properly. This wreaks havoc on your cat’s entire GI tract resulting in vomiting, diarrhea, and weight loss. IBD is one of the most common causes of persistent vomiting and diarrhea in cats. Unfortunately, the cause of this debilitating disease is unknown. It is seen most often is a problem in middle-aged or older cats though younger cats may be affected as well.

Symptoms

Any cat owner knows that vomiting and diarrhea occasionally happen. After all, what fun would owning a cat be without a few hairballs? With IBD, however, the vomiting and/or diarrhea become chronic, occurring regularly rather than occasionally. Cats with IBD don’t necessarily act sick, other than displaying GI symptoms.

If your pet has IBD, you may notice the following:

• Diarrhea

• Blood or mucus in stool

• Black, tarry stool (melena)

• Gas

• Straining to defecate

• Weight loss

• Increased or decreased appetite

• Lethargy

• Vomiting

• Accidents outside the litter pan

Diagnosis

Diagnosing IBD begins with a thorough physical examination and tests to rule out other possible causes of the diarrhea and/or vomiting. These tests may include the following:

• Chemistry tests to evaluate kidney, liver, and pancreatic function as well as sugar levels

• A complete blood count (CBC) to assess for infection, anemia, and other problems

• Electrolyte tests to ensure your cat is neither dehydrated nor suffering from an electrolyte imbalance

• X-rays of the abdomen to rule out GI obstruction, foreign body or masses

• An ultrasound to evaluate the integrity of your cat’s digestive tract, pancreas, and other organs

• Specific tests to rule out viral infections such as feline leukemia or feline immunodeficiency virus

• Fecal tests to identify potential fecal parasites

• Special fecal tests, such as cultures and polymerase chain reaction (PCR) testing

• Intestinal biopsy using endoscopy, laparoscopy, or surgery to allow definitive diagnosis

Treatment

Upon diagnosing IBD in your cat, your veterinarian may recommend medications that will treat your pet's symptoms. These may include:

• Dietary modification to decrease antigenic stimulation of the GI tract

• Deworming to treat undetected intestinal parasite

• Antibiotics to treat overgrowth of bacteria

• Corticosteroids to minimize inflammation

• Others – probiotics, vitamin B12, antiemetic’s, additional medication to suppress the immune system

When treating IBD, it is very important to administer all medications prescribed by your veterinarian, as well as to follow any dietary guidelines he or she suggests.

Prevention

Unfortunately, there are no preventive measures that will protect your cat from inflammatory bowel disease.

If you have any questions or concerns, you should always visit or call your veterinarian – they are your best resource to ensure the health and well-being of your pets.

---

Hear From Us Again

Don't forget to subscribe to our email newsletter for more recipes, articles, and clinic updates delivered straight to your e-mail inbox.

Related Categories:

Cat Health

Get to Know Your Dog’s Digestive System

A healthy digestive system is essential to your dog’s well-being. The digestive system serves many important functions: it takes in food, absorbs nutrients, maintains fluid and electrolyte balance, and gets rid of waste.

It also covers a lot of area. The digestive tract includes the oral cavity (salivary glands, tongue, teeth), esophagus, stomach, small and large intestine, liver, pancreas, rectum, and anus.

The canine digestive system isn’t the most glamorous topic, but understanding how it works puts you in a better position to determine if your dog is sick and needs to be seen by a vet. It can also guide you in making decisions that will enhance their health.

Here are 7 interesting facts about your dog's gastrointestinal tract and health!

1. Dogs Get Heartburn, Too

Dogs can get indigestion and heartburn just like humans.

In the fasted state, stomach acids are very similar in people and dogs. After eating, however, dogs produce more acid than we do.

Our similarities mean that dogs and people benefit from the same antacids. But before giving your dog an over-the-counter antacid, talk to your veterinarian. You will want to be sure you aren’t risking any potential drug interactions or side effects.

Veterinarians can also provide you with important usage guidance for antacids to ensure you are not putting your pet’s health at risk.

But more stomach acid doesn’t translate to letting your dog eat potentially contaminated foods. Dogs are no less sensitive to food poisoning (bacterial contamination) than are people. The practice of feeding raw meat to dogs carries a demonstrated risk of food poisoning.

2. Food Moves Through a Dog's GI Tract Three Times as Fast

Dogs have a small intestine that occupies about 25% of the total gastrointestinal volume, which is consistent with other omnivores, including people. The small intestine of a cat, a true carnivore, occupies only 15%.

On average, food moves through the canine stomach a bit slower than ours, but food movement through the intestines is a little faster. Gastrointestinal transit time is six to eight hours for dogs, while in people it’s between 20 and 30 hours.

3. Dogs Can’t Chew Side to Side

You’ve probably noticed that your dog can’t chew side to side. The dog’s jaw only allows for up and down motion when chewing, whereas people have side-to-side movement that allows more grinding of food.

The difference probably has to do with our historical diets. The wolf-like ancestors of dogs ate mostly meat that could be easily ripped and swallowed, but people also relied on gathering or farming plant material that required more chewing.

4. Most Dogs Can Digest and Absorb Carbs

But modern dogs are considered omnivores, just like we are. They originally ate a carnivorous diet in the wild, but since they have been domesticated, adaptions have been made that allow them to digest and utilize plant-based nutrients.

True carnivores, like cats, have a higher nutritional requirement for taurine, arachidonic acid and certain vitamins, which are available in animal fat and protein sources.

Omnivores don’t have a higher requirement for these and create their own arachidonic acid from vegetable oils. Most normal dogs have no difficulty digesting and absorbing carbohydrates. So, there is no benefit to feeding grain-free diets to normal dogs.

5. Cholesterol Doesn’t Impact a Dog’s Health

Your doctor may advise you to lower your cholesterol level, but you won’t hear the same concerns echoed at the vet’s office. Cholesterol does not have the same effect on your dog’s heart, and their digestive systems are designed to accommodate animal fat.

Dogs also don’t have the same issues with colon cancer, so the idea that eating foods high in soluble fiber or low in saturated or trans-fats will provide any health benefit is really unknown at this point.

Vets say one of the keys to health is keeping your dog at a healthy weight. Obesity is related to exacerbation of many health problems in dogs and is a vet’s number one battle. If it’s any one thing that we can do, it’s talk to our vets about how to curb obesity.

6. Diarrhea and Vomiting May Be Bigger Problems Than You Thought

Gastrointestinal diseases account for about 10% of veterinary visits. Diarrhea is one of the most frequent clinical signs. Abnormal stool may also be a first symptom of a more systemic disease process, such as kidney, liver, and some endocrine disorders.

Vomiting is also a common symptom. An acute bout may resolve itself over a day or two—vets will often recommend a short, 12-hour period of fasting to “rest” the GI tract, followed by a bland diet of chicken and rice. But when the clinical signs continue or are especially severe, testing is often recommended to attempt to find out what may be causing the distress.

Imbalances with other organs, such as the kidneys, can also cause gastrointestinal signs. It is important to see your vet to determine the best treatment for your dog.

7. Your Dog’s Poop Tells a Lot About Their Health

You can learn a lot about your dog’s health by studying her poop (an unpleasant, but necessary task).

There are a variety of causes for abnormal stool. Most episodes of acute onset diarrhea are typically self-limiting within a few days, as dietary indiscretions are a frequent cause.

Parasites, bacteria, and viruses may also cause diarrhea. Depending on the underlying cause, the animal may or may not need appropriate treatment for the infectious agent. If diarrhea persists for several days, and/or there is blood in the stool, the animal should be examined by a veterinarian who can determine the most appropriate course of treatment.

On the other hand, if your dog isn’t pooping and is straining to defecate, they may be constipated, which if prolonged, may cause serious health issues.

One important takeaway is to contact your vet if you notice anything suspicious. Even short episodes of diarrhea or constipation that occur periodically, especially in combination with other signs, like weight loss and loss of appetite, may indicate a more complicated disease process.

Another key point is that you regularly monitor your dog’s poop habits. It is important for the owner to daily monitor how often the animal defecates and the consistency of the stool. There is some variation between animals and also variation from day-to-day, with some animals having consistently softer stools or harder stools than others. But generally, with time, the owners should be able to establish what’s normal for their animal.

---

Hear From Us Again

Don't forget to subscribe to our email newsletter for more recipes, articles, and clinic updates delivered straight to your e-mail inbox.

Related Categories:

dog health

Diabetes Ketoacidosis (DKA) - A Complication of Diabetes in Cats and Dogs

Unfortunately, as veterinarians, we are seeing an increased prevalence of diabetes mellitus in dogs and cats. This is likely due to the growing prevalence of obesity (secondary to inactive lifestyle, a high carbohydrate diet, lack of exercise, etc.). You're probably wondering if you just had a dog or cat diagnosed with diabetes mellitus—what do you do? First, we encourage you to take a look at these articles for an explanation of the disease:

• Diabetes in Cats

• Diabetes in Dogs

This article will teach you about life-threatening complications that can occur as a result of the disease; specifically, a life-threatening condition called diabetes ketoacidosis (DKA) so that you know how to help prevent it.

What is DKA?

When diabetes goes undiagnosed or difficult to control or regulate, the complication of DKA can occur. DKA develops because the body is so lacking in insulin that the sugar can’t get into the cells — resulting in cell starvation. Cell starvation causes the body to start breaking down fat in an attempt to provide energy (or a fuel source) to the body. Unfortunately, these fat breakdown products, called “ketones,” are also poisonous to the body.

Symptoms of DKA

Clinical signs of DKA include the following:

• Weakness

• Not moving (in cats, hanging out by the water bowl)

• Not eating or complete anorexia

• Vomiting

• Excessive thirst and urination (clear, dilute urine)

• Large urinary clumps in the litter box (anything bigger than a tennis ball is abnormal)

• Weight loss (most commonly over the back), despite an overweight body condition

• Obesity

• Flaky skin coat

• Excessively dry or oily skin coat

• Abnormal breath (typically a sweet “ketotic” odor)

• Diarrhea
  

In severe cases DKA can also result in more significant signs:

• Abnormal breathing pattern

• Jaundice

• Abdominal pain (sometimes due to the secondary problem of pancreatitis)

• Tremors or seizures

• Coma

• Death

What can cause DKA?

When DKA occurs, it’s often triggered by an underlying medical problem such as an infection or metabolic (organ) problem. Some common problems that we see with DKA include the following:

• Pancreatitis

• Urinary tract infection

• Chronic kidney failure

• Endocrine diseases (e.g., hyperadrenocorticism [when the body makes too much steroid], or hyperthyroidism [an overactive thyroid gland])

• Lung disease (such as pneumonia)

• Heart disease (such as congestive heart failure)

• Liver disease (such as fatty changes to the liver)

• Cancer

Diagnosing DKA

While diagnosing DKA is simple, by looking at the blood sugar levels of dogs and cats and by measuring the presence of these fat breakdown products in the urine or blood, treatment can be costly (running between $3-5000). A battery of tests and diagnostics need to be performed, to look for underlying problems listed above, and treatment typically requires aggressive therapy and 24/7 hospitalization.

Treatment of DKA

Treatment, typically, is required for 3-7 days, and includes the following:

• A special intravenous catheter called a “central line” (placed to aid in frequent blood draws)

• Aggressive intravenous fluids

• Electrolyte supplementation and monitoring

• Blood sugar monitoring

• A fast acting or ultra fast acting insulin, regular or Lispro, typically given intravenously or in the muscle

• Blood pressure monitoring

• Nutritional support (often in the form of a temporary feeding tube)

• Anti-vomiting or anti-nausea medication

• Antibiotics

• Long-term blood sugar monitoring and a transition to a longer-acting insulin

Thankfully, with aggressive supportive care, many patients with DKA do well as long as pet parents are prepared for the long-term commitment (including twice-a-day insulin, frequent veterinary visits to monitor the blood sugar, and the ongoing costs of insulin, syringes, etc.).

Preventing DKA

By following your veterinarian’s guidelines and recommendations you can help regulate and control your pet’s diabetic state better and monitor your pet carefully for clinical signs. For example, if your pet is still excessively thirsty or urinating frequently despite insulin therapy, they are likely poorly controlled and need an adjustment of their insulin dose (of course, never adjust your pet’s insulin or medications without consulting your veterinarian).

When in doubt remember that the sooner you detect a problem in your dog or cat, the less expensive that problem is to treat. If you notice any clinical signs of diabetes mellitus or DKA, seek immediate veterinary attention. Most importantly, blood glucose curves (when a veterinarian measures your pet’s response to their insulin level) often need to be done multiple times per year (especially in the beginning stages of diabetes mellitus).

If you have any questions or concerns, you should always visit or call your veterinarian.

Related reading:

• Diabetes in Cats

• Diabetes in Dogs

---

Hear From Us Again

Don't forget to subscribe to our email newsletter for more recipes, articles, and clinic updates delivered straight to your e-mail inbox.

Related Categories:

dog health, cat health