Feline Distemper (or Feline Panleukopenia Virus)

What is Feline Distemper / FPV in Cats?

FPV / Feline Panleukopenia Virus, otherwise known as Feline Distemper, is a highly contagious, life-threatening infectious disease in cats. It mostly affects kittens and unvaccinated cats, and it can be fatal if not appropriately diagnosed and treated. It is closely related to canine parvovirus (often confused as it is not related to the canine distemper virus).

The feline panleukopenia virus infects and kills the rapidly growing and dividing cells in the body, including cells in the bone marrow, intestines, and skin, and in a developing fetus.

The virus suppresses the production of all white blood cells in the bone marrow. These cells are important to the immune system and are used to fight infection. Without them, the cat is vulnerable to spreading the virus.

Infected cells in the intestines eventually lead to diarrhea, decreased appetite and vomiting. Severe dehydration ensues and the safety barrier between the intestines and the rest of the body breaks down, leading to secondary bacterial infections. The virus spreads quickly and is fatal, if left untreated.

Feline distemper virus is found everywhere in the environment; it is strong and can live for years. The virus can survive in the environment it was shed into or be carried on shoes, paws, bedding, bowls, litter boxes, etc. It can survive at freezing temperatures and room temperatures, and it can also survive the use of certain disinfectants, including iodine and alcohol.

The virus enters the body through the nose or mouth; the specific cat’s immune system determines the number of viral particles that enter the body. Usually, the virus invades the bone marrow and intestines within two to seven days of the cat coming into contact with the virus.

Panleukopenia is considered one of the deadliest cat diseases in the unvaccinated cat population. Kittens, cats with depressed immune systems and pregnant cats are at the highest risk to develop severe clinical signs of this disease.

Symptoms of Feline Distemper / FPV

Symptoms of feline distemper can range from mild to severe and may include the following:

• Lethargy

• Depression

• Vomiting

• Diarrhea

• Painful abdomen (when touched or may appear tense and distended without touching)

• Dehydration

• Weight loss

• Rough or unkempt hair coat

• Fever

• Decreased to absent appetite

• Collapse (in severe cases)

• Bruising of the skin or gums (in severe cases)

Kittens infected in the womb during the late stages of pregnancy may develop cerebellar hypoplasia once born, a condition where the virus affects the formation of a part of the brain called the cerebellum. This is the part that coordinates balance and movement.

Affected kittens will have mild to severe intention tremors and a wide-based stance. They may fall frequently or seem uncoordinated. Luckily, this is not considered a painful condition, and these special-need kittens, if kept in safe environments, can live long happy lives.

Causes of Feline Distemper / FPV

Cats become infected with this virus in utero due to their mother becoming infected while pregnant or being exposed to it in their environment. Kittens can also be infected in utero or via breast milk when feeding from their mother.

A cat carrying feline distemper virus will shed viral particles into the environment through feces, urine, saliva and vomit. Infection occurs when susceptible cats are in contact with these secretions.

Luckily, an infected cat only sheds the virus for a day or two, but since the virus is very stable in the environment, it can live for years. That is why it is common for cats to become infected due to their environment.

Diagnosing Feline Distemper / FPV

Feline panleukopenia can look like many other conditions, such as feline leukemia or feline immunodeficiency virus. Any kitten showing signs of fever, vomiting, diarrhea, depression, and a decreased appetite is a feline panleukopenia suspect. A thorough medical history can be helpful with diagnosis, especially if your cat was recently adopted, has been outdoors frequently, is unvaccinated, and/or has been around other cats.

Your veterinarian will likely do bloodwork to help with the diagnosis. Feline panleukopenia is suspected when exposure history is correlated with very low white blood cells and possibly low red blood cells (anemia).

Fecal testing for feline panleukopenia virus can be performed . If the cat received a panleukopenia vaccine 5-12 days prior to testing, this form of test is often falsely positive. Virus isolation (a test to find the virus in different tissue samples), antibody levels and PCR testing are also available to help confirm suspicions of feline panleukopenia.

Treatment of Feline Distemper / FPV

There is no specific treatment for feline panleukopenia. Dehydration is treated with aggressive intravenous fluid therapy while clinical signs of vomiting and diarrhea are treated with prescription medications.

Antibiotic therapy is often instituted to help control any secondary bacterial infections due to low white blood cell counts. However, antibiotics are not used to treat and clear the actual virus. For kittens and cats who appear in shock, or with severe infections, aggressive therapy and nursing care is necessary for resuscitation, using plasma/blood transfusions and anti-coagulant therapies.

Luckily, cats who do receive and respond well to aggressive therapy during the first few days of feline panleukopenia tend to have a good prognosis for a complete recovery. Kittens infected in utero during the early to middle stages of pregnancy typically do not survive. Those infected in the later stages of pregnancy tend to develop cerebellar hypoplasia but can live happy lives with normal survival times, depending on the severity of the neurological signs.

Prognosis decreases for cats with low protein levels, low temperatures, thin body conditions, and/or severely low white blood cells on bloodwork. These extremely ill cats have a poor prognosis and, on average, will pass away within 12-24 hours.

If a cat recovers from feline panleukopenia, there is usually no permanent damage to their organs, and they develop lifelong immunity to the virus.

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Cat Health

Chronic Kidney Disease in Cats

What is chronic kidney disease in cats?

Chronic kidney disease (CKD) is the persistent loss of kidney function over time. Healthy kidneys perform many important functions, most notably filtering the blood and making urine, so problems with kidney function can result in a variety of health problems for a cat. Among the many different kidney diseases that may affect cats, CKD is the most common.

The kidneys are part of the renal system, the body’s system for filtering impurities out of the blood. Urine produced in the kidneys is carried to the bladder by the ureters and from the urinary bladder to the outside world by the urethra.

Clinical Signs and Symptoms of Chronic Kidney Disease in Cats

Cats with CKD may experience a buildup of the waste products and other compounds in the bloodstream that are normally removed or regulated by the kidneys. This accumulation may make them feel ill and appear lethargic, unkempt, and lose weight. They may also lose the ability to concentrate their urine appropriately, and as a result they may urinate greater volumes and drink more water to compensate. The loss of important proteins and vitamins in their urine may contribute to abnormal metabolism and loss of appetite. They may also experience elevated blood pressure (hypertension), which can affect the function of a number of important systems, including the eyes, brain, and heart.

Another cause of lethargy in cats with CKD is the buildup of acids in their blood. The kidneys of cats with CKD may not excrete these compounds appropriately, making affected cats prone to blood acidification, or acidosis, a condition that can significantly affect the function of a variety of organ systems in the body. CKD may also decrease a cat’s ability to produce red blood cells, which can lead to anemia, a reduced concentration of red blood cells in their blood. This may cause their gums to appear pale pink, or in severe cases, whitish in color, and may make them lethargic.

Diagnosis of Chronic Kidney Disease in Cats

To evaluate kidney function, veterinarians will most often turn to blood tests and urine analysis (urinalysis) to evaluate the concentrations of waste products and other components that healthy kidneys normally filter or regulate.

Blood tests can determine the concentration of two important waste products: blood urea nitrogen (BUN) and creatinine, but creatinine is generally recognized as a more specific indicator of kidney function. An increase in the concentration of these compounds in your cat’s blood may suggest that his kidneys are not functioning properly, although these values must be interpreted in light of a number of factors. Dehydration, for example, can cause BUN and creatinine concentrations to increase in spite of the fact that a cat’s kidneys are functioning normally. Ideally, a veterinarian will base his or her interpretation of kidney function on at least two blood samples, obtained within two weeks of one another, from a normally hydrated cat that has fasted for 12-24 hours. The concentrations of other blood components, including various electrolytes (like sodium and potassium), phosphorus, red blood cells, and proteins are also important to evaluate in a cat being examined for CKD.

In a urinalysis, your veterinarian will consider the concentration of the urine, its pH, and the presence of protein, blood cells, bacteria, and other cells that generally should not be found in feline urine, all of which provide important information regarding the health of a cat’s kidneys. It is also important to culture a urine sample to rule out the possibility of bacterial infection of the urinary tract in suspected cases of CKD. Urine samples may be obtained either by collection from a litter box filled with non-absorbent beads designed for this purpose, by catheterization of the urethra (the opening of the urinary tract to the outside world), or by cystocentesis, a technique that extracts a urine sample by passing a very fine needle through the abdominal wall into the bladder. Cystocentesis is generally considered a safe procedure and in most cases will provide the most diagnostically useful sample for analysis.

Other studies that can be useful in evaluating a cat with suspected CKD include imaging studies such as abdominal ultrasound, radiographs (X-rays), and, in some cases, microscopic evaluation of biopsy samples. Given the potential for hypertension in cats with CKD, measurement of a cat’s blood pressure is also an important part of the medical evaluation for this disease.

Treatment of Chronic Kidney Disease in Cats

Although there is no definitive cure for CKD, treatment can improve and prolong the lives of cats with this disease. Therapy is geared toward minimizing the buildup of toxic waste products in the bloodstream, maintaining adequate hydration, addressing disturbances in electrolyte concentration, supporting appropriate nutrition, controlling blood pressure, and slowing the progression of kidney disease.

Dietary modification is an important and proven aspect of CKD treatment. Studies suggest that therapeutic diets that are restricted in protein, phosphorus and sodium content and high in water-soluble vitamins, fiber, and antioxidant concentrations may prolong life and improve quality of life in cats with CKD. However, many cats have difficulty accepting therapeutic diets, so owners must be patient and dedicated to sticking to the plan. It is important to make a gradual transition to a therapeutic diet and to consider food temperature, texture, and flavor. Cats with CKD that go without food for relatively short periods of time may develop significant health problems, so it is crucial to make sure that your cat is eating during a transition to a therapeutic diet.

Controlling hypertension, decreasing urinary protein loss, and addressing anemia are important therapeutic goals in cats that develop these conditions. Hypertension is usually controlled with oral medication, and urinary protein loss may be treated with angiotensin converting enzyme inhibitors. Anemia in a cat with CKD may be treated by replacement therapy with erythropoietin (or with related compounds), which stimulates red blood cell production. Cats with CKD may produce less erythropoietin, and there is some evidence that replacement therapy can increase red blood cell counts. In some cases, blood transfusions, which may be used to restore normal red blood cell concentrations using blood obtained from a donor cat, may be necessary.

Although a number of other therapies, including phosphate binders, potassium supplementation, antioxidant supplementation, alkalinization therapy, and administration of fluids either intravenously or subcutaneously, have the potential to help cats with CKD, these approaches have not been fully validated, and controlled studies are needed to determine whether they offer any benefits. The same is true of hemodialysis (the removal of toxic waste products from the bloodstream by specially designed equipment) and kidney transplantation. These controversial, complex, and expensive treatments offer potential benefits to cats with CKD, but they have not been subjected to studies to prove their effectiveness, so they should be explored with the careful guidance of a veterinary specialist.

Prognosis of Chronic Kidney Disease in Cats

Some cats respond very well to treatment for CKD while others do not, so the prognosis for CKD in affected cats is quite variable. Some studies suggest that cats that lose more protein in their urine have less favorable prognoses. There is evidence suggesting that the earlier CKD is diagnosed and treatment is initiated, the better the outcome with respect to quality of life and survival.

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Cat Vomiting, Diarrhea, Bloody Stool - Irritable Bowel Disease in Cats

Overview and Risk

Inflammatory bowel disease (IBD) is a condition that results when your cat’s immune system turns against the lining of their gastrointestinal (GI) tract, resulting in impaired absorption of nutrients and the ability to digest food properly. This wreaks havoc on your cat’s entire GI tract resulting in vomiting, diarrhea, and weight loss. IBD is one of the most common causes of persistent vomiting and diarrhea in cats. Unfortunately, the cause of this debilitating disease is unknown. It is seen most often is a problem in middle-aged or older cats though younger cats may be affected as well.

Symptoms

Any cat owner knows that vomiting and diarrhea occasionally happen. After all, what fun would owning a cat be without a few hairballs? With IBD, however, the vomiting and/or diarrhea become chronic, occurring regularly rather than occasionally. Cats with IBD don’t necessarily act sick, other than displaying GI symptoms.

If your pet has IBD, you may notice the following:

• Diarrhea

• Blood or mucus in stool

• Black, tarry stool (melena)

• Gas

• Straining to defecate

• Weight loss

• Increased or decreased appetite

• Lethargy

• Vomiting

• Accidents outside the litter pan

Diagnosis

Diagnosing IBD begins with a thorough physical examination and tests to rule out other possible causes of the diarrhea and/or vomiting. These tests may include the following:

• Chemistry tests to evaluate kidney, liver, and pancreatic function as well as sugar levels

• A complete blood count (CBC) to assess for infection, anemia, and other problems

• Electrolyte tests to ensure your cat is neither dehydrated nor suffering from an electrolyte imbalance

• X-rays of the abdomen to rule out GI obstruction, foreign body or masses

• An ultrasound to evaluate the integrity of your cat’s digestive tract, pancreas, and other organs

• Specific tests to rule out viral infections such as feline leukemia or feline immunodeficiency virus

• Fecal tests to identify potential fecal parasites

• Special fecal tests, such as cultures and polymerase chain reaction (PCR) testing

• Intestinal biopsy using endoscopy, laparoscopy, or surgery to allow definitive diagnosis

Treatment

Upon diagnosing IBD in your cat, your veterinarian may recommend medications that will treat your pet's symptoms. These may include:

• Dietary modification to decrease antigenic stimulation of the GI tract

• Deworming to treat undetected intestinal parasite

• Antibiotics to treat overgrowth of bacteria

• Corticosteroids to minimize inflammation

• Others – probiotics, vitamin B12, antiemetic’s, additional medication to suppress the immune system

When treating IBD, it is very important to administer all medications prescribed by your veterinarian, as well as to follow any dietary guidelines he or she suggests.

Prevention

Unfortunately, there are no preventive measures that will protect your cat from inflammatory bowel disease.

If you have any questions or concerns, you should always visit or call your veterinarian – they are your best resource to ensure the health and well-being of your pets.

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Fungal Disease in Amphibians (Chytridiomycosis)

Chytridiomycosis

Chytridiomycosis is a serious infectious disease caused by Batrachochytrium dendrobatidis, a zoosporic fungus related to water molds. The fungus feeds on keratin, a protein found in the outermost layers of the skin, and survives in most environments, even without a host. It is believed that the decrease in the population of frogs in many areas is due to chytridiomycosis.

A common way to recognize chytridiomycosis is to check your amphibian's skin for sloughing or shedding. The disease can be fatal for amphibians left untreated. Therefore, owners suspecting chytridiomycosis in their amphibian must seek immediate veterinary care.

Symptoms and Types

An amphibian suffering from chytridiomycosis may shed excessively, develop thickened or pale skin and, in the cases of tadpoles, disfigured beaks. Other common symptoms or signs include:

• Lethargy

• Loss of appetite (anorexia)

• Constriction of the eye's pupil

• Abnormal posture of the hind legs

• Abnormal behavior and disposition

• Hyperemia (an increase in blood flow to different body tissues)

Some amphibians present no clinical symptoms of the disease, but are still infected with the Batrachochytrium dendrobatidis fungus. These animals are carriers of the disease.

Causes

Chytridiomycosis is due to an infection with the B. dendrobatidis fungus. Generally, amphibians contract the fungus through their skin while in contaminated water.

Diagnosis

Veterinarians diagnose the disease by examining skin scrapings or toe clips that are stained and put under a light microscope. Placing an infected animal in a shallow dish of water will often confirm the sloughing of skin, a common symptom for chytridiomycosis.

Treatment

To treat chytridiomycosis, your veterinarian will prescribe antifungal medication, such as itraconazol, which is usually diluted and administered as a bath. Supplemental treatment may include ultraviolet light therapy.

Living and Management

For unknown reasons, chytrid infections have a high mortality rate. Therefore, it is important you follow your veterinarian's instructions and provide a clean aquatic environment and an appropriate temperature range for your amphibian.

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small / exotic pet care

Let's talk about cat poop!

Healthy Poop in Cats

How often should a cat 'go'?

The general rule of thumb is that a cat should poop at least once a day. However, the frequency of your cat's bowel movements is affected by multiple factors including the age (i.e. kittens defecate more often than adults), diet, exercise, and health status (i.e. IBD, hyperthyroidism, parasites, CKD).

Because of this, the exact frequency of the bowel movement will be individual, and you should monitor for its fluctuations instead. If your cat's bowel movements start to differ from the normal frequency for longer than a day or two, it is advisable to pay a visit to the vet and resolve the cause of the change.

What does healthy poop look like?

Healthy cat poop should be deep brown in color (but not too dark nor black) and malleable in consistency (similar to modeling clay; it should be firm enough to leave little to no residue on the ground when picked up, yet pliable and not too hard). Poop should be passed in one piece or a few smaller pieces of somewhat cylindrical shape and segmented appearance. The odor shouldn't be too foul, although this can be variable.

Unhealthy Poop in Cats

The key signs to look out for in your cat's poop are the consistency, shape and color. The stool's consistency is directly influenced by the amount of moisture in it, which gives you an insight into the colonic health. The colon (or the large intestine) reabsorbs the remaining water and other key nutrients from the indigestible material, thus solidifying this material into the firm stool. The consistency of the stool can be descriptively scored to help you recognize if your cat's stool is healthy.

A comprehensive fecal scoring guide was described by Purina. According to Purina's guide, the consistency of the healthy stool can be scored on the scale from 1 to 7. The healthy stool (as described above) is scored with 2, while the stool that is too hard and dry is scored with 1. Scores from 3 to 7 are reserved for moist, mushy or liquid stools.

Hard stool (score 1) is typically a sign of constipation, which can be associated with dehydration, colon obstruction or certain metabolic and neurological conditions. Thus, if you notice that your cat is passing poop that is too hard in consistency, you should pay a visit to the vet and address the issue. The hard poop is passed in smaller, more spherical pellets which leave no residue on the ground, and the passing itself requires more effort.

Soft, mushy or liquid stools (scores 3-7) can be a sign of bacterial infections, intestinal parasites, or food intolerance. If your cat's poop is moist on the surface, thus leaving residue on the ground, but retains the shape and form when picked up, then its consistency can be scored with 3. This poop has little to no visible segmentation, but is not considered to be an alarming sign.

If the poop is so moist that it feels saggy and it loses form when picked up (but does retain a logged shape when passed), then the consistency can be scored with 4. Furthermore, if the stool is passed in a pile rather than the logs, then it is scored with 5. If your cat passes liquid stool with texture but no shape, then the consistency is scored with 6. Liquid stool without any texture nor shape is scored with 7.

Soft or fluid stool (as described by the scores 4-7), accompanied by a more frequent bowel movement, are referred to as diarrhea. While the causes for diarrhea are variable and often multi-factorial, this state is considered to be an important, sign of underlying problems and is a legitimate reason to consult with your vet. Sometimes, diarrhea can be caused by stress (i.e. moving to a new environment or bringing in a new pet), or food allergies and intolerance.

Other times, however, diarrhea can be a symptom of a disease, a bacterial infection, or even intestinal parasites. If your cat is suffering from diarrhea, make sure to closely monitor the frequency on your cat's bowel movement, so you can report it to your veterinarian. Keep an eye on other signs of disease and injury and the changes in your cat's behavior. This will be key for the diagnosis of the underlying cause.

Contact your veterinarian ASAP after spotting the symptoms, especially if diarrhea persists for more than two days and is accompanied by lack of appetite, lethargy, or vomiting. The veterinarian will diagnose the underlying cause and help you design a special recovery diet for your cat until it recovers.

The stool is a direct insight into its colonic health. It can help you recognize if your cat is eating the right diet and drinking enough water or if it's suffering from certain health problems. So, the next time you clean the litter box, make sure to quickly inspect if your cat's poop is healthy! A healthy cat is a happy cat.

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